The approval of the WEGO series of culture media for listing has attracted widespread attention in the industry, demonstrating the company's research and development innovation capabilities and enriching new breakthroughs in key technologies of Chinese enterprises in the field of assisted reproduction. This not only marks WEGO's further achievements in the field of assisted reproduction, but also represents that domestic assisted reproductive medical products are firmly moving towards perfection and comprehensiveness with the support of national policies.

The development and upgrading of WEGO culture medium cannot be separated from sincere cooperation with renowned assisted reproductive technology experts and research institutes at home and abroad. In late June, Wang Weihua, the chief expert of WEGO reproduction and internationally renowned embryologist, and Wang Tao, returned to China specifically for guidance.

Experts return to China for comprehensive guidance

Dr. Wang Weihua serves as the director of PRELUDE Houston Embryo Laboratory and the director of five well-known IVF clinics in the United States. He was the first to carry out blastocyst culture, embryo vitrification freezing, pre implantation chromosome detection using gene chips and sequencing technology, egg freezing, and the establishment of an egg bank in the United States. His research achievements have won the gold medal at the American Society for Reproductive Medicine conference. For more than 20 years, he has been engaged in embryology research and clinical work. He has profound scientific attainments in the fields of basic research of assisted reproductive medicine, research and development of new assisted reproductive technologies, and translational medicine. His research and development achievements of new assisted reproductive technologies, such as vitrification of embryos and eggs, implantation diagnosis technology of embryos, etc., have been recognized and highly praised by the world's peers, and he has guided the clinical and laboratory work of assisted reproductive departments in the first tier three tier hospitals in China. He is a candidate of the “Hundred Talents Program” of the Institute of Chinese Academy of Sciences, a researcher of the State Key Laboratory of Reproductive Biology of the Chinese Academy of Sciences, and a winner of the National Science Fund for Distinguished Young Scholars. Professor Wang Tao is a technician at the Embryology Laboratory of the Houston Fertility Institute, particularly skilled in techniques such as egg freezing and embryo biopsy, and has published multiple related papers.

As the chief expert and technical consultant of WEGO Assisted Reproduction, Dr. Wang Weihua and his wife led the development of WEGO culture medium and guided our laboratory operation technology and mouse embryo quality control technology.

Optimize production processes and enhance research and development plans

In order to better serve market demand, the first stop for the two experts after returning to Weihai was to visit the reproductive center and receive practical training on the WEGO Vitrification Kit and Warming Kit. With a combination of theory and practice, the training mode not only provides effective solutions for practical operational problems that may arise after the product is launched, but also provides detailed explanations of the technical points and precautions in the freezing and thawing process, greatly improving the business level of our R&D and marketing personnel.

In order to further achieve excellent performance of the product, Dr. Wang Weihua visited our production workshop for exchange and guidance, reviewed the production process of the culture medium product, and listened to detailed introductions from the company's R&D personnel. This trip not only reminded the key control points that need to be paid attention to in the liquid R&D process from the perspective of product use, but also proposed an optimization plan for the culture medium production process on how to provide high-quality embryo culture systems for reproductive clinical use, providing an integrated solution for product R&D innovation, and providing cutting-edge technology for the product quality control laboratory.

Strengthen the quality control of mouse embryos and overcome innovative difficulties

After selecting technical experts to study at the Guangzhou Institute of Biomedical and Health Sciences and the Institute of Zoology, Chinese Academy of Sciences, in order to improve the quality control of mouse embryos to the top level in China, our company has specially invited Dr. Wang Weihua to give a full demonstration and explanation on the vitrification freezing and thawing operations of mouse eggs and embryos. Starting from the differences in the prokaryotic and two cell stages of mouse eggs and fertilized embryos, embryo recovery, freezing carriers, operation time, morphological characteristics of thawed cells, and in vitro development, this study explores the developmental ability of mouse embryos after vitrification cryopreservation. By optimizing the freezing method and embryo culture conditions, a suitable freezing preservation program for mouse oocytes and embryos at different stages and an in vitro development system after thawing were established, forming an economical, effective, and stable plan for mouse embryo freezing. This provides sufficient experimental materials for the company's ongoing embryo analysis biology research. During the process, students actively practiced and discussed difficult and doubtful points with experts in depth. Through this training, our technical personnel have further mastered the freezing and thawing technology of mouse embryos, which can better serve our product quality control and provide different stages of frozen mouse embryos for institutions and units across the country that need to conduct mouse embryo testing/quality control.

In the special discussion, Dr. Wang Weihua combined industry trends and cutting-edge information to provide development directions and methods around the clinical characteristics of reproduction, the development of new products for assisted reproductive medical devices, and the key technical difficulties of “neck sticking” in the research and development process. He stated that now everyone has a more comprehensive understanding of the principles and operational details of freezing and thawing technology, and learns to think about the differences in operation habits among reproductive clinicians. This will definitely enable targeted improvement, refinement, and iteration of products, fully applying experience to the process of product research and development innovation, and laying a solid foundation for the company and even the industry to innovate research results and promote technological progress in the industry.